role of distribution of malasezia furfur serovars, propionibacteria and micrococcaceae in the pathogenesis of tinea versicolor and seborrhoeic dermatitis

This study was designed to compare the distribution of M. Furfur serovars [A, B and C], Propionibacteria and Micrococcaceae on the chest, face, back and scalp of 40 patients with tinea versicolor [TV] and ten matched controls and 40 patients with seborrhoeic dermatitis [SD] and ten matched controls. The patients and controls were sampled from the mentioned sites and cultured aerobically for Micrococcaceae and M. furfur and anaerobically for Propionibacteria. Serotyping of M. Furfur was carried out to identify the three serovars A, B and C. There was no difference in either the Micrococcaceae or Propionibacteria results in patients groups compared with control skin. Regarding the results of M. furfur, serovar A predominated in the back lesions in both patients groups when compared with the control. Serovar A was also predominant in the face lesions but only in seborrhoeic dermatitis patients, serovar C predominated in all sites [in both patient groups] and serovar B predominated in all lesions of TV patients and in the back, face and neck in SD patients

Detection of some types of human papillomaviruses in skin tags

Human papilloma virus [HPV] DNA of types 6, 11, 16, 18, 31, 33, 52b and 58 was searched by polymerase chain reaction in skin tag biopsies, mononuclear cells, sera and normal skin of 28 patients with multiple skin tags and in 10 normal subjects. Histopathological examination of skin biopsies was done. Fasting blood glucose, serum cholesterol and triglycerides were determined in patients and controls. The results showed that 96% of the patients had HPV DNA in their skin tags, 71% had HPV types 6 and 11 and 25% had HPV types 16 and 18, in addition to type 6 and 11. The histopathological examination revealed an increasing epithelial hyperplasia, hyperkeratosis and parakeratosis and increasing epidermal cells with perinuclear membrane irregularities in 25% of the cases with mixed viral infections. Only HPV DNA of types 6 and 11 was detected in mononuclear cells of the patients and in their sera